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Long-term use of anti-TNF-alpha agents can lead to the development of autoantibodies. Infliximab ( Remicade ) is a chimeric human-murine monoclonal antibody that inhibits TNF-alpha. Investigator ...


A study, led by Nancy A. Nussmeier at the Texas Heart Institute, St. Luke's Episcopal Hospital, in Houston, assessed the safety of Valdecoxib ( Bextra ) and its intravenous prodrug Parecoxib ( Dynasta ...


A prospective cohort study found that Tumour Necrosis Factor alpha ( TNF-alpha ) blocking agents, trigger skin conditions in 25% of patients with rheumatoid arthtitis. TNF-alpha blocking agents has ...


The FDA ( Food and Drug Administration ) announced a series of important changes pertaining to the marketing of the non-steroidal anti-inflammatory class of drugs, including COX-2 selective and prescr ...


A Phase III clinical study of Rituximab ( Rituxan ) met its primary endpoint of a greater proportion of Rituximab-treated patients achieving an American College of Rheumatology ( ACR ) 20 response at ...


Hylan G-F 20 ( Synvisc ) is an elastoviscous fluid containing hylan polymers, which are derivatives of hyaluronan ( sodium Hyaluronate). It is indicated for the treatment of pain caused by osteoarth ...


FDA ( Food and Drug Administration ) has approved Remicade ( Infliximab ) to reduce the signs and symptoms of active arthritis in patients with psoriatic arthritis. Psoriatic arthritis affects ap ...


Researchers from the Baylor Institute for Immunology Research in Dallas report on the successful treatment of children with systemic onset juvenile idiopathic arthritis ( SoJIA ) in whom previous ther ...


Study suggests continuous NSAID treatment more effectively reduces X-Ray progression than intermittent treatment. A widely under-recognized form of arthritis, ankylosing spondylitis ( AS ) is a chr ...


Drugs blocking the action of TNF ( Tumor Necrosis Factor ) have shown promise in the early treatment of rheumatoid arthritis. To expand the understanding of TNF's function in chronic inflammatory ...


Patients with rheumatoid arthritis, whose joint damage is inhibited through a combination therapy of Adalimumab ( Humira ) and Methotrexate early in the course of their disease are less likely to expe ...


Preliminary results from a large randomized clinical trial of Rituximab ( Rituxan ) in rheumatoid arthritis showed that a greater proportion of patients treated with a single course of Rituximab, with ...


A research has showed that gene therapy for arthritis and other non-terminal, debilitating conditions and diseases is both feasible and safe. This is the world’s first gene therapy trial in patient ...


It is known that Aspirin, a non-selective, non-steroidal anti-inflammatory drug ( NSAID ) that inhibits cyclooxygenase ( COX ), reduces the risk of myocardial infarction and stroke. Non-aspirin non-s ...


The cellular signaling protein Wnt, which is involved in embryonic development and cancer, contributes to disease progression of both rheumatoid arthritis and osteoarthritis. Wnt is best known as a ...