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Search results for "Lupus"

Long-term use of anti-TNF-alpha agents can lead to the development of autoantibodies. Infliximab ( Remicade ) is a chimeric human-murine monoclonal antibody that inhibits TNF-alpha. Investigator ...


Drugs blocking the action of TNF ( Tumor Necrosis Factor ) have shown promise in the early treatment of rheumatoid arthritis. To expand the understanding of TNF's function in chronic inflammatory ...


Rituximab ( Rituxan ), a drug used to treat cancer, may also benefit people with lupus erythematosus who have complications of the central nervous system. Lupus is a disorder of the immune system i ...


Women with rheumatic disease experience greater pregnancy risks and longer hospital stays than the average pregnant woman. The findings from the Stanford University School of Medicine provide women ...


Rheumatoid arthritis ( RA ) is an autoimmune disease characterized by chronic inflammation of the joints, which gradually erodes the cartilage and bone. The agents of destruction include inflammatory ...


A study, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the National Institutes of Health ( NIH ), has found that women with either inactive or ...


Researchers at Wake Forest University School of Medicine and the University of Virginia hope to reset part of the "epigenetic code" in lupus patients. The epigenetic research focuses on histones, t ...


A animal research at Wake Forest University School of Medicine, found that a common anti-seizure drug may be effective against certain conditions associated with lupus. The drug, Valproic acid ( D ...


Treatment with Belimumab ( Benlysta ) resulted in a sustained improvement of systemic lupus erythematosus ( SLE or lupus ) disease activity in 46% of patients at week 52.Historically, it has been diff ...


The 36% of patients with refractory systemic lupus erythematosus ( SLE or lupus ) remain stable after undergoing B-cell depletion therapy ( BCDT ) without needing further standard immunosuppressive ag ...


Systemic lupus erythematosus ( SLE ) can affect nearly any part of the body, including the joints, skin, kidneys, heart, nervous system, and brain. Along with joint pain, muscle pain, unexplained feve ...


Dipeptidyl peptidase-4 inhibitors ( DPP4i ), such as Linagliptin, Saxagliptin, and Sitagliptin, are oral glucose-lowering drugs for type 2 diabetes mellitus ( T2DM ). DPP4 is a transmembrane glycoprot ...


Eli Lilly has announced that it will discontinue the phase 3 rheumatoid arthritis ( RA ) program for Tabalumab, an anti-BAFF ( B cell activating factor ) monoclonal antibody, due to lack of efficacy. ...


Plasmacytoid dendritic cells have been implicated in the pathogenesis of systemic sclerosis through mechanisms beyond the previously suggested production of type I interferon.Researchers have isolated ...


Mavrilimumab and Sifalimumab have met their primary endpoints in respective phase II studies, demonstrating further pipeline progress in core therapeutic areas. Mavrilimumab, an investigational mon ...