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Gout increases the risk of deep vein thrombosis and pulmonary embolism


Previous studies indicated that gout is a risk factor of cardiovascular diseases. This study aimed to determine if patients with gout have an increased risk of deep vein thrombosis ( DVT ) or pulmonary embolism ( PE ).

Researchers used the Longitudinal Health Insurance Database, a subset of the national insurance claim dataset, which enrolled 1 million Taiwanese to identify 57,981 patients with gout and 115,961 reference subjects matched by sex, age, and entry date of diagnosis.

In this Taiwanese dataset observed from 2000 to 2010, researchers found the incidence of deep vein thrombosis was 5.26 per 10 person-years in the gout cohort, which was twofold higher than the incidence of 2.63 per 10 person-years in the reference cohort.

After adjusting for age, sex, and 9 comorbidities, the hazard ratio ( HR ) of developing deep vein thrombosis was 1.66 ( 95% confidence interval [ CI ] = 1.37-2.01 ).

Among patients with gout, the youngest age group had the highest increase in the risk of developing deep vein thrombosis ( HR [ 95% CI ] = 2.04 [ 1.24-3.37 ] for ages 20 to 49 years, 1.80 [ 1.28-2.51 ] for ages 50 to 64 years, and 1.45 [ 1.11-1.91 ] for ages greater than or equal to 65 years ).

The incidence of pulmonary embolism was about one-fifth that of deep vein thrombosis in gout patients, but the effect of gout on the risk was similar ( HR [ 95% CI ] = 1.53 [ 1.01-2.29 ] ).
This analysis confirmed that gout increased the risk of deep vein thrombosis and pulmonary embolism. ( Xagena )

Huang CC et al, Medicine ( Baltimore ) 2015;94(51):e2140. doi: 10.1097/MD.0000000000002140.

XagenaMedicine_2015



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