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Patients with gout linked to high risk of depressive disorders, antigout medications reduce the risk

Metabolic abnormalities are common in patients with depressive disorders. However, the relationship between gout and depression is unclear.

Researchers explored the causal relationship among gout, antigout medication, and the associated risk of incidental depressive disorders.

In this nationwide cohort study, researchers sampled data from the National Health Insurance Research Database ( NHIRD ) to recruit 34,050 patients with gout as the gout cohort and 68,100 controls ( without gout ) as the nongout cohort.

The primary endpoint was the diagnosis of depressive disorders during follow-up.

The overall study population was followed up until depression diagnosis, withdrawal from the NHI program, or the end of the study.

Patients with gout exhibited a higher risk of depressive disorders than controls did.

The risk of depressive disorders increased with age and was higher in female patients and those with hypertension, stroke, and coronary artery disease.

Nonsteroidal antiinflammatory drug and Prednisolone use was associated with a reduced risk of depression.

Patients with gout who had received antigout medication exhibited a reduced risk of depressive disorders compared with nongout patients.

These findings support that gout increases the risk of depressive disorders, and that antigout medication use reduces the risk. ( Xagena )

Changchien TC et al, Medicine ( Baltimore ). 2015;94(52):e2401. doi: 10.1097/MD.0000000000002401.