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Anifrolumab is an investigational, fully human monoclonal antibody that binds to subunit 1 of the type I IFN receptor, inhibiting the activity of all type I IFNs, which play a central role in lupus, i ...


The results from the phase III study known as GiACTA, which evaluated Tocilizumab ( Actemra, RoActemra ), an anti-IL-6 receptor monoclonal antibody, in people with giant cell arteritis ( GCA ) were pr ...


Cardiovascular disease ( CVD ) is the leading cause of death in rheumatoid arthritis ( RA ) patients. This study is the first to report the association of Hydroxychloroquine ( Plaquenil; an antirheuma ...


IL-6 is one of the most abundant cytokines in the serum and synovial fluid of patients with rheumatoid arthritis ( RA ). In rheumatoid arthritis, IL-6 is synthesized and secreted by cells of the sy ...


Synovial joint damage is mediated by cells of the pannus. In rheumatoid arthritis, there is a marked increase in proliferation, or hyperplasia, of cells of the synovial intimal lining, which include f ...


Psoriatic arthritis patients treated with Ixekizumab ( Taltz ) for 24 weeks have achieved significant improvements in signs and symptoms of their disease when compared to placebo, while also experienc ...


Researchers have evaluated the current evidence of the effectiveness of Botulinum toxin ( BTX ) treatment for shoulder pain. Randomized controlled trials comparing the clinical efficacy ( pain inte ...


Metabolic abnormalities are common in patients with depressive disorders. However, the relationship between gout and depression is unclear. Researchers explored the causal relationship among gout, ...


The extent of lung involvement visualized by high-resolution computed tomography ( HRCT ) is a predictor of decline in forced vital capacity ( FVC ) in scleroderma-interstitial lung disease. The obj ...


Systemic sclerosis ( SSc ) is the most severe connective tissue disorder. Recent studies have demonstrated that genetic factors may play a role in the development of systemic sclerosis. The aim of t ...


Primary Sjögren syndrome ( PSS ) is a chronic inflammatory autoimmune disease. Interstitial lung disease ( ILD ) can be an extraglandular complication. A multicentre cohort study has evaluated the ...


Kawasaki disease ( KD ) is also known as multiple mucocutaneous lymph node syndrome of systemic vasculitis and is a leading cause of coronary artery lesions ( CAL ) in childhood. Intravenous immunog ...


Takayasu's arteritis ( TAK ) is a chronic, large-vessel vasculitis. Vitamin D, as a steroidal hormone, has recently been shown to have immunoregulatory and immunosuppressive effects. Low vitamin D l ...


A study aimed to assess the relative efficacy and safety of biologics and Tofacitinib ( Xeljanz ) in patients with rheumatoid arthritis showing an inadequate response to tumor necrosis factor ( TNF ) ...


In Behcet's disease ( BD ), interleukin-6 ( IL-6 ) drive the immune-mediated inflammatory process. The IL-6 receptor can be targeted using Tocilizumab ( RoActemra ). As an off-label treatment, resea ...